Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.60 |
| ▸ | CCND1 | P24385 | 19/20 | 0.60 |
| ▸ | CCND2 | P30279 | 19/20 | 0.60 |
| ▸ | CCND3 | P30281 | 19/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.60 |
| ▸ | CDK1 | P06493 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.60 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.60 |
| ▸ | CDK2 | P24941 | 4/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808764 | 0.97 | CDK4 (0.64) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6812213 | 0.93 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7505247 | 0.90 | CDK4 (0.61) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7506755 | 0.89 | CDK4 (0.60) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6808330 | 0.87 | CDK4 (0.65) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7507690 | 0.87 | CDK4 (0.64) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL6808128 | 0.86 | CDK4 (0.64) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7505654 | 0.86 | CDK4 (0.63) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7500850 | 0.84 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL7505972 | 0.84 | CDK4 (0.63) | CDK4CCND1CCND2CCND3CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255755-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001055148-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | claimed |
| EP-1255755-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001055148-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |