Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.76 |
| ▸ | PDE2A | O00408 | 1/20 | 0.76 |
| ▸ | PDE1A | P54750 | 1/20 | 0.76 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.76 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496280 | 0.90 | PDE5A (0.76) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7500002 | 0.90 | PDE5A (0.76) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7497773 | 0.87 | PDE5A (0.72) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL492485 | 0.87 | PDE5A (1.00) | PDE5APDE2APDE1APDE1BPDE1C | |
| Hydrochloric Acid SCHEMBL27383537 | 0.86 | PDE5A (0.98) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7497147 | 0.85 | PDE5A (0.73) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7496355 | 0.85 | PDE5A (0.70) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7503292 | 0.85 | PDE5A (0.69) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7496606 | 0.85 | PDE5A (0.69) | PDE5APDE2APDE1APDE1BPDE1C | |
| SCHEMBL7497449 | 0.83 | PDE5A (0.61) | PDE5APDE2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607439-B1 | NITROGENOUS HETEROCYCLIC COMPOUND | EISAI CO LTD (JP) | 2002-01-09 | — | — | EP | disclosed |
| US-6046206-A | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives | CELL PATHWAYS, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5801180-A | ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | EISAI CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5693652-A | Benzimidazoles for ischemic heart conditions | EISAI CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| US-5576322-A | Anti-ischemic 2,4-diaminoquinazolines | EISAI CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0607439-A1 | NITROGENOUS HETEROCYCLIC COMPOUND | Eisai Co., Ltd. (JP) | 1994-07-27 | — | — | EP | disclosed |
| CN-1071164-A | Nitrogen-containing heterocycle compound | EISAI CO LTD (JP) | 1993-04-21 | — | — | CN | disclosed |