SCHEMBL7500394

SCHEMBL7500394

CCOC(=O)CC(C[N+](=O)[O-])C(COCOC)NC(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTT P42858 1/20 0.38
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34
TP53 P04637 1/20 0.33
CTSK P43235 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
CYP2D6 P10635 1/20 0.32
GSTP1 P09211 1/20 0.32
GSTM2 P28161 1/20 0.32
TSHR P16473 1/20 0.31
KLK5 Q9Y337 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7501049 0.84 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL7504990 0.84 CYP1A2 (0.41) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL7501377 0.83 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL7501369 0.83 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL7501362 0.83 CYP1A2 (0.37) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL19200954 0.81 CYP1A2 (0.43) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL22866107 0.70 CYP1A2 (0.55) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL31402184 0.70 CA1 (0.59) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL20877749 0.70 CA1 (0.59) CYP1A2CYP2C9CYP2C19HTTCA1
SCHEMBL7501052 0.69 CA1 (0.41) CA1CA2CA7CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0723545-B1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LAB (US) 2002-05-08 EP disclosed
EP-0871628-A1 QUINOLIZINONE TYPE COMPOUNDS Abbott Laboratories (US) 1998-10-21 EP disclosed
US-5726182-A TREATMENT OF BACTERIAL INFECTIONS ABBOTT LABORATORIES (US) 1998-03-10 US disclosed
US-5599816-A BACTERICIDE ABBOTT LABORATORIES (US) 1997-02-04 US disclosed
WO-1996039407-A1 QUINOLIZINONE TYPE COMPOUNDS ABBOTT LABORATORIES (US) 1996-12-12 WO disclosed
US-5580872-A ADMINISTERING IN THE TREATMENT OF BACTERIAL INFECTIONS ABBOTT LABORATORIES (US) 1996-12-03 US disclosed