SCHEMBL7500732

SCHEMBL7500732

CC(O)(CCCCNC(=O)Nc1cccc(C#N)c1)CN1CCC(Cc2ccc(F)cc2)CC1

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 20/20 0.75
HTR2A P28223 6/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6329316 0.87 CCR3 (0.95) CCR3HTR2A
SCHEMBL6338760 0.86 CCR3 (1.00) CCR3HTR2A
SCHEMBL6333363 0.80 CCR3 (1.00) CCR3HTR2A
SCHEMBL6215479 0.80 CCR3 (0.75) CCR3HTR2A
SCHEMBL6335930 0.79 CCR3 (0.95) CCR3HTR2A
SCHEMBL6337783 0.79 CCR3 (1.00) CCR3HTR2A
SCHEMBL6328728 0.79 CCR3 (1.00) CCR3HTR2A
SCHEMBL6215640 0.78 CCR3 (1.00) CCR3HTR2A
SCHEMBL6218137 0.78 CCR3 (0.73) CCR3HTR2A
SCHEMBL6218549 0.78 CCR3 (0.73) CCR3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1158980-A4 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARM CO (US) 2002-04-03 EP claimed
EP-1158980-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Du Pont Pharmaceuticals Company (US) 2001-12-05 EP claimed
WO-2000035453-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARMACEUTICALS COMPANY (US) 2000-06-22 WO claimed