SCHEMBL7500756

SCHEMBL7500756

N#Cc1cccc(NC(=O)N[C@@H]([CH]CN2CCC(Cc3ccc(F)cc3)CC2)Cc2ccccc2)c1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 20/20 0.64
HTR2A P28223 3/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6218516 0.85 CCR3 (0.69) CCR3HTR2A
SCHEMBL6213440 0.85 CCR3 (0.69) CCR3HTR2A
SCHEMBL6213438 0.85 CCR3 (0.69) CCR3HTR2A
SCHEMBL6218478 0.82 CCR3 (0.62) CCR3HTR2A
SCHEMBL6217190 0.82 CCR3 (0.62) CCR3HTR2A
SCHEMBL6214027 0.82 CCR3 (0.71) CCR3HTR2A
SCHEMBL6214028 0.82 CCR3 (0.71) CCR3HTR2A
SCHEMBL6329419 0.82 CCR3 (0.69) CCR3HTR2A
SCHEMBL6217159 0.82 CCR3 (0.71) CCR3HTR2A
SCHEMBL6213066 0.80 CCR3 (0.70) CCR3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1158980-A4 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARM CO (US) 2002-04-03 EP disclosed
EP-1158980-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Du Pont Pharmaceuticals Company (US) 2001-12-05 EP disclosed
WO-2000035453-A1 N-UREIDOALKYL-PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY DU PONT PHARMACEUTICALS COMPANY (US) 2000-06-22 WO disclosed