Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.55 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.53 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | FADS1 | O60427 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7502970 | 0.99 | EGFR (0.57) | EGFRABL1CDK1SRCTTBK1 | |
| SCHEMBL7498606 | 0.90 | BRAF (0.66) | EGFRABL1CDK1SRCTTBK1 | |
| Bromide SCHEMBL7498610 | 0.89 | BRAF (0.65) | EGFRABL1CDK1SRCTTBK1 | |
| SCHEMBL4773624 | 0.88 | EGFR (0.59) | EGFRABL1CDK1TTBK1TTBK2 | |
| SCHEMBL2461054 | 0.88 | BRAF (0.64) | EGFRABL1CDK1SRCTTBK1 | |
| SCHEMBL8256959 | 0.86 | EIF2AK2 (0.62) | EGFRTTBK1TTBK2BRAFTNNI3K | |
| SCHEMBL27442803 | 0.86 | BRAF (0.62) | EGFRABL1CDK1SRCTTBK1 | |
| SCHEMBL7491484 | 0.85 | TTBK1 (0.54) | EGFRABL1TTBK1TTBK2BRAF | |
| SCHEMBL4770048 | 0.85 | EGFR (0.60) | EGFRABL1CDK1SRCTTBK1 | |
| SCHEMBL7496440 | 0.84 | ABCG2 (0.53) | EGFRTTBK1TTBK2BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1100778-C | Pyrrolopyrimidines and process for their preparation | NOVARTIS CO (CH) | 2003-02-05 | — | — | CN | claimed |
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | claimed |
| CN-1194647-A | Pyrrolopyrimidines and processes for preparation thereof | NOVARTIS CO (CH) | 1998-09-30 | — | — | CN | claimed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | claimed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | claimed |