Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956384 | 0.91 | CCNT1 (0.46) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL6947835 | 0.90 | CCNT1 (0.44) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL7508601 | 0.89 | CCNT1 (0.47) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL6954175 | 0.88 | CCNT1 (0.43) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL7164524 | 0.88 | CCNT1 (0.47) | CCNT1CDK9CDK2CCNA2 | |
| Hydrochloric Acid SCHEMBL6954170 | 0.87 | CCNT1 (0.42) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL6950505 | 0.87 | CCNT1 (0.42) | CCNT1CDK9CDK2CCNA2MEN1 | |
| SCHEMBL7134999 | 0.87 | CDK2 (0.42) | CCNT1CDK9CDK2CCNA2 | |
| SCHEMBL6948115 | 0.87 | CCNT1 (0.41) | CCNT1CDK9CDK2CCNA2MEN1 | |
| SCHEMBL6951202 | 0.87 | CCNT1 (0.43) | CCNT1CDK9CDK2CCNA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1155595-C | Substituted pyrroles as antiproliferative agents for the treatment of cancer | - | 2004-06-30 | — | — | CN | disclosed |
| CN-1378545-A | Substituted pyrroles as antiproliferative agents for treatment of cancer | HOFFMANN LA ROCHE (CH) | 2002-11-06 | — | — | CN | disclosed |
| EP-1224181-A1 | SUBSTITUTED PYRROLES AS ANTIPROLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027106-A1 | SUBSTITUTED PYRROLES AS ANTIPROLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-19 | — | — | WO | disclosed |