Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 12/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7110501 | 0.91 | CXCR2 (0.48) | CXCR2TSHRATMCNR1LMNA | |
| SCHEMBL7118983 | 0.91 | CXCR2 (0.43) | CXCR2ATMCNR1KMT2APOLB | |
| SCHEMBL27552475 | 0.89 | CXCR2 (0.41) | CXCR2TSHRATMCNR1POLB | |
| SCHEMBL27552190 | 0.88 | CXCR2 (0.41) | CXCR2TSHRATMCNR1POLB | |
| SCHEMBL27571760 | 0.86 | CXCR2 (0.45) | CXCR2TSHRATMCNR1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7500081 | 0.84 | CXCR2 (0.51) | CXCR2ATMCNR1LMNAKMT2A | |
| SCHEMBL2533467 | 0.83 | CXCR2 (0.51) | CXCR2TSHRKMT2ACX3CR1 | |
| SCHEMBL28748189 | 0.82 | CXCR2 (0.50) | CXCR2TSHRKMT2ACX3CR1 | |
| SCHEMBL27753417 | 0.81 | CXCR2 (0.59) | CXCR2 | |
| SCHEMBL7692368 | 0.80 | CXCR2 (0.36) | CXCR2ATMCNR1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161232-A4 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1161232-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000035442-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |