Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 16/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392686 | 0.94 | TACR2 (0.49) | TACR2KCNH2HRH1SSTR5 | |
| SCHEMBL7490246 | 0.93 | TACR2 (0.48) | TACR2KCNH2HRH1SSTR5 | |
| SCHEMBL7500566 | 0.91 | HRH1 (0.44) | TACR2KCNH2OPRD1HRH1SSTR5 | |
| SCHEMBL7498745 | 0.90 | SSTR5 (0.49) | TACR2KCNH2OPRD1HRH1SSTR5 | |
| SCHEMBL7547390 | 0.90 | TACR2 (0.52) | TACR2 | |
| SCHEMBL7496899 | 0.90 | HRH1 (0.46) | TACR2KCNH2OPRD1HRH1SSTR5 | |
| SCHEMBL7498324 | 0.90 | TACR2 (0.52) | TACR2 | |
| SCHEMBL7495363 | 0.89 | TACR2 (0.51) | TACR2 | |
| SCHEMBL7498099 | 0.89 | SSTR5 (0.48) | TACR2KCNH2OPRD1HRH1SSTR5 | |
| SCHEMBL7493809 | 0.89 | KCNH2 (0.51) | TACR2KCNH2OPRD1HRH1SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |