Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL748625 | 0.80 | GRM2 (0.60) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL19633031 | 0.78 | GRM2 (0.51) | GRM2KCNH2 | |
| SCHEMBL20842325 | 0.78 | GRM2 (0.53) | GRM2KCNH2 | |
| SCHEMBL10819352 | 0.77 | GRM2 (0.75) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL10321779 | 0.77 | GRM2 (0.77) | GRM2SLC6A3 | |
| SCHEMBL745634 | 0.76 | GRM2 (1.00) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL10322030 | 0.75 | GRM2 (0.72) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL20836090 | 0.74 | GRM2 (0.53) | GRM2CYP2C9CYP2C19SLC6A3SIGMAR1 | |
| SCHEMBL16731497 | 0.72 | GRM2 (0.78) | GRM2 | |
| SCHEMBL10321242 | 0.71 | GRM2 (0.76) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430022-A1 | 1,2,3-TRIAZOLO Ý4,3-A¨PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | Janssen Pharmaceuticals, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130424-A9 | 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2010130424-A1 | 1,2,3-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2010-11-18 | — | — | WO | disclosed |