Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8605589 | 0.98 | PPARA (0.57) | PPARAKCNH2PTGS2NPC1RAB9A | |
| SCHEMBL25801691 | 0.86 | PPARA (0.60) | PPARAKCNH2PTGS2CHRM2CHRM4 | |
| SCHEMBL369102 | 0.85 | PPARA (0.71) | PPARAKCNH2PTGS2NPC1RAB9A | |
| SCHEMBL7686496 | 0.83 | PPARA (0.64) | PPARAKCNH2PTGS2NPC1RAB9A | |
| SCHEMBL7505230 | 0.83 | PPARA (0.64) | PPARAKCNH2PTGS2NPC1RAB9A | |
| SCHEMBL8605187 | 0.81 | PPARA (0.57) | PPARAKCNH2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2094373 | 0.80 | PPARA (0.57) | PPARAKCNH2PTGS2 | |
| SCHEMBL3812770 | 0.80 | PPARA (0.65) | PPARAKCNH2PTGS2NPC1RAB9A | |
| SCHEMBL2094371 | 0.79 | PPARA (0.56) | PPARAKCNH2PTGS2 | |
| SCHEMBL7504627 | 0.78 | PPARA (0.54) | PPARAKCNH2PTGS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684945-B1 | PYRAZOLE- OR ISOXAZOLE-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER LAMBERT CO (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1203767-A1 | Heterocyclic-substituted alkylamide acat inhibitors | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| US-5693657-A | USEFUL FOR TREATING HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5646170-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0684945-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5441975-A | Anticholesterol agent | WARNER-LAMBERT COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| US-5366987-A | Enzyme inhibitors, anticholesterol | WARNER-LAMBERT COMPANY (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1994019330-A1 | HETEROCYCLIC-SUBSTITUTED ALKYL AMIDE ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-09-01 | — | — | WO | disclosed |