Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.69 |
| ▸ | CCND1 | P24385 | 13/20 | 0.69 |
| ▸ | CCND2 | P30279 | 13/20 | 0.69 |
| ▸ | CCND3 | P30281 | 13/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5268129 | 0.89 | CDK4 (0.79) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5265687 | 0.85 | CDK4 (0.68) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5267347 | 0.82 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL10192690 | 0.81 | CDK4 (0.79) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5263052 | 0.80 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5265231 | 0.80 | CDK4 (0.68) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL10192646 | 0.80 | CDK4 (0.77) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5268660 | 0.79 | CDK4 (0.90) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5264508 | 0.79 | CDK4 (0.79) | CDK4CCND1CCND2CCND3CCNE2 | |
| SCHEMBL5266379 | 0.79 | CDK4 (0.75) | CDK4CCND1CCND2CCND3CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255755-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001055148-A1 | PYRIDOPYRIMIDINONE DERIVATIVES FOR TREATMENT OF NEURODEGENERATIVE DISEASE | WARNER-LAMBERT COMPANY (US) | 2001-08-02 | — | — | WO | disclosed |