SCHEMBL750674

SCHEMBL750674

CCCOCc1nnc2c(C(F)(F)F)c(N3CCC(F)(c4ccccc4)CC3)ccn12

nearest known ligand 0.68

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 20/20 0.68
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
SLC6A3 Q01959 1/20 0.47
SIGMAR1 Q99720 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10322475 0.93 GRM2 (0.70) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL10322605 0.86 GRM2 (0.78) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL6926142 0.86 GRM2 (0.69) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL745634 0.81 GRM2 (1.00) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL10322252 0.78 GRM2 (0.71) GRM2
SCHEMBL10321594 0.75 GRM2 (0.80) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL17570189 0.74 GRM2 (0.55) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL750719 0.73 GRM2 (0.81) GRM2CYP2C9CYP2C19SLC6A3SIGMAR1
SCHEMBL10322790 0.73 GRM2 (0.75) GRM2
SCHEMBL747890 0.73 GRM2 (0.69) GRM2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430022-A1 1,2,3-TRIAZOLO Ý4,3-A¨PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS Janssen Pharmaceuticals, Inc. (US) 2012-03-21 EP disclosed
WO-2010130424-A9 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2011-01-27 WO disclosed
WO-2010130424-A1 1,2,3-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2010-11-18 WO disclosed