Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347436 | 0.93 | MAPKAPK2 (0.51) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7851175 | 0.87 | KDM4E (0.52) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL4743709 | 0.87 | BAZ2B (0.56) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7505356 | 0.84 | ABCG2 (0.44) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7842410 | 0.83 | ELANE (0.51) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7508089 | 0.83 | KDM4E (0.51) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7852233 | 0.82 | CYP1A2 (0.56) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7851318 | 0.81 | KDM4E (0.48) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL8035810 | 0.81 | KDR (0.57) | MAPKAPK2KDM4ENPC1POLBRAB9A | |
| SCHEMBL7851640 | 0.81 | MAPT (0.60) | MAPKAPK2KDM4ENPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781281-B1 | BETA-CARBOLINE DERIVATIVES AS MELATONIN AGONISTS, METHODS FOR THEIR PREPARATION AND THEIR USE AS DRUGS | MACEF (FR) | 2001-12-19 | — | — | EP | claimed |
| EP-1091959-B1 | NOVEL PYRROLO-(3,4-B)QUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICAMENT | MACEF (FR) | 2002-10-23 | — | — | EP | disclosed |
| US-6335346-B1 | HYPNOTIC AGENTS, SEDATIVES | MACEF (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-0781281-B1 | BETA-CARBOLINE DERIVATIVES AS MELATONIN AGONISTS, METHODS FOR THEIR PREPARATION AND THEIR USE AS DRUGS | MACEF (FR) | 2001-12-19 | — | — | EP | disclosed |
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |
| EP-0781281-A1 | NOVEL MELATONIN AGONIST $g(b)-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS | CEMAF (FR) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008490-A1 | NOVEL MELATONIN AGONIST β-CARBOLINE DERIVATIVES AND ANALOGS WITH A NAPHTHALENIC STRUCTURE, METHOD FOR THEIR PREPARATION AND THEIR USE AS DRUGS | CEMAF (FR) | 1996-03-21 | — | — | WO | disclosed |