⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29467654 | 1.00 | — | — | |
| SCHEMBL176779 | 1.00 | — | — | |
| SCHEMBL164553 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL29668865 | 0.98 | SLC6A2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL14738827 | 0.98 | SLC6A2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL29467669 | 0.98 | SLC6A2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL5552719 | 0.98 | SLC6A2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL2674033 | 0.98 | SLC6A2 (0.48) | — | |
| SCHEMBL10932213 | 0.98 | SLC6A2 (0.48) | — | |
| Hydrochloric Acid SCHEMBL30567628 | 0.98 | SLC6A2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 272 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119119035-A | RIPK1 kinase target inhibitor and preparation method and application thereof | 中山大学 | 2024-12-13 | — | — | CN | claimed |
| CN-115260199-A | Benzimidazole pyrazine-3-carboxamide compound and preparation method and application thereof | 中山大学 | 2022-11-01 | — | — | CN | claimed |
| EP-2771327-B1 | NOVEL PYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-11-16 | — | — | EP | claimed |
| US-9403808-B2 | Pyrazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-08-02 | — | — | US | claimed |
| US-20130109665-A1 | NOVEL PYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-05-02 | — | — | US | claimed |
| US-20070117858-A1 | SUBSTITUTED 5-HETEROARYL-1-PHENYL-PYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-05-24 | — | — | US | claimed |
| EP-1427727-B1 | COMPOUNDS WHICH INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES | PROCTER & GAMBLE (US) | 2005-01-26 | — | — | EP | claimed |
| US-6821971-B2 | FOR PROPHYALXIS OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE (IBS), SEPTIC SHOCK, CARDIOPULMONARY DYSFUNCTION, ACUTE RESPIRATORY DISEASE, CACHEXIA | THE PROCTER & GAMBLE COMPANY | 2004-11-23 | — | — | US | claimed |
| EP-1427727-A1 | COMPOUNDS WHICH INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-06-16 | — | — | EP | claimed |
| US-20030105084-A1 | Compound which inhibit the release of inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-06-05 | — | — | US | claimed |
| WO-2003024970-A1 | COMPOUNDS WHICH INHIBIT THE RELEASE OF INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | claimed |
| JP-10251231-A | — | — | None | — | — | JP | disclosed |
| CN-122055144-A | Compounds and methods for treating cancer | 维瓦斯治疗公司 | 2026-05-15 | — | — | CN | disclosed |
| US-12617746-B2 | Method of preparing triterpenoid compound | NATIONAL TAIWAN UNIVERSITY (TW) | 2026-05-05 | — | — | US | disclosed |
| US-12600709-B2 | Nonpeptide somatostatin type 5 receptor agonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2026-04-14 | — | — | US | disclosed |
| US-6369075-B1 | 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B | PFIZER, INC. | 2002-04-09 | — | — | US | disclosed |
| WO-2001064994-A1 | METHOD FOR REDUCING DYE FADING OF FABRICS IN LAUNDRY BLEACHING COMPOSITIONS | UNILEVER PLC (GB) | 2001-09-07 | — | — | WO | disclosed |
| EP-1099442-A2 | Methods of administering apo B-secretion/MTP inhibitors | Pfizer Products Inc. (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1099701-A1 | 7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B | Pfizer Products Inc. (US) | 2001-05-16 | — | — | EP | disclosed |
| JP-H10251231-A | OPTICALLY ACTIVE PYRIDYLETHYLAMINES AND ITS PRODUCTION | UBE IND LTD | 1998-09-22 | — | — | JP | disclosed |