Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.66 |
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7503404 | 0.89 | MKNK1 (0.59) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7505150 | 0.88 | LCK (0.55) | LCKMKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL7502642 | 0.88 | MKNK1 (0.60) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7502913 | 0.88 | MKNK1 (0.62) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7499363 | 0.87 | MKNK1 (0.67) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7502691 | 0.87 | MKNK1 (0.61) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7504903 | 0.87 | MKNK1 (0.61) | LCKMKNK1MKNK2ADRA2BADRA2C | |
| SCHEMBL7498441 | 0.87 | LCK (0.53) | LCKMKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL7500919 | 0.86 | LCK (0.54) | LCKMKNK1MKNK2KDM4EALDH1A1 | |
| SCHEMBL7497560 | 0.85 | MKNK1 (0.64) | LCKMKNK1MKNK2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | claimed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | claimed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | claimed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |