Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 19/20 | 0.73 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL7511690 | 0.96 | P2RY12 (0.72) | P2RY12USP28 | |
| SCHEMBL6997872 | 0.94 | P2RY12 (0.68) | P2RY12 | |
| SCHEMBL2067079 | 0.93 | P2RY12 (0.73) | P2RY12 | |
| SCHEMBL7515280 | 0.92 | P2RY12 (0.66) | P2RY12 | |
| SCHEMBL7512097 | 0.90 | P2RY12 (0.62) | P2RY12 | |
| Bicarbonate SCHEMBL7511337 | 0.89 | P2RY12 (0.63) | P2RY12USP28 | |
| SCHEMBL7510944 | 0.89 | P2RY12 (0.61) | P2RY12 | |
| SCHEMBL7508486 | 0.89 | P2RY12 (0.61) | P2RY12 | |
| Bicarbonate SCHEMBL7509640 | 0.89 | P2RY12 (0.66) | P2RY12 | |
| Carbamic Acid SCHEMBL7515314 | 0.88 | P2RY12 (0.61) | P2RY12USP28 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946561-B1 | TRIAZOLO(4,5-D)PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |