Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.53 |
| ▸ | ESR1 | P03372 | 13/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.53 |
| ▸ | TOP1 | P11387 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505259 | 1.00 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL8693023 | 1.00 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7506382 | 1.00 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7499905 | 1.00 | HRAS (0.53) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL7504096 | 0.99 | KDM4E (0.54) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL7512754 | 0.99 | KDM4E (0.54) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL7506706 | 0.99 | KDM4E (0.54) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7503323 | 0.94 | HRAS (0.43) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7510696 | 0.93 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7507423 | 0.93 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722446-B1 | DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-12-11 | — | — | EP | disclosed |
| US-5753629-A | AMINO ACID DERIVATIVE ANTIBIOTICS; VIRICIDES | PHARMACIA S.P.A. (IT) | 1998-05-19 | — | — | US | disclosed |