Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222400 | 0.87 | MEN1 (0.69) | MEN1KMT2APOLBTP53MAPT | |
| SCHEMBL6224299 | 0.87 | MEN1 (0.52) | MEN1KMT2APOLBTP53 | |
| SCHEMBL6605747 | 0.82 | MEN1 (0.75) | MEN1KMT2APOLBTP53MAPT | |
| SCHEMBL6605741 | 0.82 | MEN1 (0.75) | MEN1KMT2APOLBTP53MAPT | |
| SCHEMBL7511484 | 0.77 | TP53 (0.55) | MEN1KMT2APOLBALDH1A1TP53 | |
| SCHEMBL7511492 | 0.77 | TP53 (0.55) | MEN1KMT2APOLBALDH1A1TP53 | |
| SCHEMBL6601524 | 0.77 | MEN1 (0.58) | MEN1KMT2A | |
| SCHEMBL6601529 | 0.77 | MEN1 (0.58) | MEN1KMT2A | |
| SCHEMBL6219696 | 0.75 | POLB (0.56) | MEN1KMT2APOLBALDH1A1MAPT | |
| SCHEMBL7516846 | 0.75 | MEN1 (0.44) | MEN1KMT2APOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |