Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 13/20 | 0.62 |
| ▸ | GRIN2B | Q13224 | 13/20 | 0.62 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510782 | 0.88 | GRIN1 (0.64) | GRIN1GRIN2BSLC22A12F2 | |
| SCHEMBL7513116 | 0.87 | GRIN1 (0.67) | GRIN1GRIN2BF2 | |
| SCHEMBL7512085 | 0.86 | GRIN1 (0.68) | GRIN1GRIN2BF2 | |
| SCHEMBL7517457 | 0.86 | GRIN1 (0.66) | GRIN1GRIN2BF2 | |
| SCHEMBL7502977 | 0.83 | GRIN1 (0.75) | GRIN1GRIN2BF2 | |
| SCHEMBL7511558 | 0.83 | GRIN1 (0.72) | GRIN1GRIN2BF2 | |
| SCHEMBL7512485 | 0.81 | GRIN1 (0.77) | GRIN1GRIN2BF2 | |
| SCHEMBL7511782 | 0.80 | GRIN1 (0.62) | GRIN1GRIN2BF2 | |
| SCHEMBL7513211 | 0.80 | GRIN1 (0.75) | GRIN1GRIN2BF2 | |
| SCHEMBL7518591 | 0.80 | GRIN1 (0.75) | GRIN1GRIN2BF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242076-A4 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1242076-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001032174-A1 | 2-BENZYL AND 2-HETEROARYL BENZIMIDAZOLE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |