Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | ELANE | P08246 | 7/20 | 0.43 |
| ▸ | CMA1 | P23946 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750422 | 0.91 | KCNH2 (0.48) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL749726 | 0.91 | KCNH2 (0.48) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL2707393 | 0.90 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL204846 | 0.90 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL18462724 | 0.90 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL13071007 | 0.85 | KCNH2 (0.53) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL13125139 | 0.82 | KCNH2 (0.58) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL17490819 | 0.81 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL18648212 | 0.81 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL17490823 | 0.81 | KCNH2 (0.70) | KCNH2CYP3A4CYP2C9CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |