Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL4557544 | 0.90 | CA4 (0.64) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL17839024 | 0.90 | CA4 (0.39) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL3916168 | 0.90 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Oxalic Acid SCHEMBL4552864 | 0.86 | CA4 (0.73) | CA4FAHD1MEN1LDHABLM | |
| Oxalic Acid SCHEMBL19371299 | 0.86 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Oxalic Acid SCHEMBL2703828 | 0.86 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Oxalic Acid SCHEMBL3263653 | 0.86 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Oxalic Acid SCHEMBL38247 | 0.86 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL2275798 | 0.84 | CA4 (0.67) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL852 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230327-A1 | FUEL ADDITIVE FOR THE PREVENTION OF VALVE SEAT RECESSION | The Associated Octel Company Limited (GB) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001016257-A1 | FUEL ADDITIVE FOR THE PREVENTION OF VALVE SEAT RECESSION | THE ASSOCIATED OCTEL COMPANY LIMITED (GB) | 2001-03-08 | — | — | WO | disclosed |