Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 6/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7513904 | 1.00 | RXFP1 (0.49) | RXFP1MAPK8DHFRMERTKTYRO3 | |
| SCHEMBL7513913 | 1.00 | RXFP1 (0.49) | RXFP1MAPK8DHFRMERTKTYRO3 | |
| SCHEMBL7520097 | 0.94 | MAPK8 (0.46) | RXFP1MAPK8MERTKTYRO3FLT3 | |
| SCHEMBL7520093 | 0.94 | MAPK8 (0.46) | RXFP1MAPK8MERTKTYRO3FLT3 | |
| SCHEMBL7510566 | 0.94 | RXFP1 (0.47) | RXFP1MAPK8DHFRFLT3IRAK1 | |
| SCHEMBL7515530 | 0.94 | RXFP1 (0.47) | RXFP1MAPK8DHFRFLT3IRAK1 | |
| SCHEMBL7510562 | 0.94 | RXFP1 (0.47) | RXFP1MAPK8DHFRFLT3IRAK1 | |
| SCHEMBL7510574 | 0.94 | RXFP1 (0.47) | RXFP1MAPK8DHFRFLT3IRAK1 | |
| SCHEMBL7515537 | 0.94 | RXFP1 (0.47) | RXFP1MAPK8DHFRFLT3IRAK1 | |
| SCHEMBL7510908 | 0.93 | RXFP1 (0.51) | RXFP1MAPK8DHFRMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | disclosed |