Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518173 | 0.95 | RXFP1 (0.51) | RXFP1LATS1LATS2DHFREGFR | |
| SCHEMBL7521450 | 0.79 | RXFP1 (0.56) | RXFP1DHFREGFRTYMSSMN1; SMN2 | |
| SCHEMBL7510622 | 0.78 | RXFP1 (0.54) | RXFP1DHFREGFRTYMSSMN1; SMN2 | |
| SCHEMBL1375573 | 0.78 | SCN9A (0.37) | LATS1LATS2P2RX7SMN1; SMN2CYP2C9 | |
| SCHEMBL1377846 | 0.77 | SCN9A (0.38) | LATS1LATS2DHFRP2RX7SMN1; SMN2 | |
| SCHEMBL7515653 | 0.77 | RXFP1 (0.62) | RXFP1DHFREGFRTYMSSMN1; SMN2 | |
| SCHEMBL1376021 | 0.76 | SCN9A (0.36) | LATS1LATS2SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL7512211 | 0.75 | RXFP1 (0.51) | RXFP1DHFREGFRTYMSSMN1; SMN2 | |
| SCHEMBL7507963 | 0.75 | RXFP1 (0.51) | RXFP1DHFREGFRTYMSSMN1; SMN2 | |
| SCHEMBL7515045 | 0.75 | RXFP1 (0.51) | RXFP1DHFREGFRTYMSSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165522-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | Krenitsky Pharmaceuticals, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059893-A1 | NEUROTROPHIC THIO SUBSTITUTED PYRIMIDINES | KRENITSKY PHARMACEUTICALS INC. (US) | 2000-10-12 | — | — | WO | claimed |