Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553283 | 0.92 | PREP (0.46) | PREPCYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL18248497 | 0.89 | PREP (0.42) | PREPCYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL4551819 | 0.86 | PREP (0.44) | PREPCYP1A2CYP2D6CYP2C19MAPK1 | |
| SCHEMBL4778263 | 0.82 | CYP2C19 (0.47) | PREPCYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL18248647 | 0.81 | SOAT1 (0.42) | PREPCYP1A2CYP2C19KMT2AMEN1 | |
| SCHEMBL18248556 | 0.81 | SOAT1 (0.42) | PREPCYP1A2CYP2C19KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6557844 | 0.81 | CYP2C19 (0.46) | PREPCYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL27574175 | 0.80 | KMT2A (0.41) | CYP1A2CYP2D6PKMSMN1; SMN2NPSR1 | |
| SCHEMBL9181327 | 0.79 | PREP (0.46) | PREPCYP1A2CYP2D6SMN1; SMN2SLC6A3 | |
| SCHEMBL18248522 | 0.79 | KDM4E (0.47) | CYP1A2CYP2C19LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |