Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19339538 | 0.90 | PRCP (0.42) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL750283 | 0.89 | PRCP (0.40) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL751761 | 0.88 | CYP3A4 (0.43) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL2710999 | 0.84 | CYP3A4 (0.53) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL19978316 | 0.84 | CYP3A4 (0.53) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL2707778 | 0.84 | CYP3A4 (0.53) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL206318 | 0.84 | CYP3A4 (0.53) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL19792243 | 0.84 | CYP3A4 (0.53) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL749933 | 0.83 | CYP2C9 (0.32) | PRCPCYP3A4CYP2C9KCNH2NR1I2 | |
| SCHEMBL19607500 | 0.82 | PRCP (0.43) | PRCPCYP3A4CYP2C9KCNH2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |