Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 1.00 |
| ▸ | ICAM1 | P05362 | 2/20 | 1.00 |
| ▸ | ITGAL | P20701 | 2/20 | 1.00 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7611387 | 0.84 | ITGB2 (0.73) | ITGB2ICAM1ITGALPDE7ACYP2A6 | |
| SCHEMBL7187676 | 0.79 | ITGB2 (0.80) | ITGB2ICAM1ITGALPDE7AALDH1A1 | |
| SCHEMBL2034515 | 0.78 | PDE7A (0.69) | ITGB2ICAM1ITGALPDE7ACYP2A6 | |
| SCHEMBL7515989 | 0.77 | ITGB2 (0.63) | ITGB2ICAM1ITGALPDE7ACYP2A6 | |
| SCHEMBL7515975 | 0.76 | ITGB2 (0.61) | ITGB2ICAM1ITGALPDE7AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7615653 | 0.76 | ITGB2 (0.70) | ITGB2ICAM1ITGALPDE7AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7611960 | 0.76 | PDE7A (0.67) | ITGB2ICAM1ITGALPDE7ACYP2A6 | |
| Hydrochloric Acid SCHEMBL7616837 | 0.76 | ITGB2 (0.64) | ITGB2ICAM1ITGALPDE7AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7609262 | 0.75 | PDE7A (0.59) | ITGB2ICAM1ITGALPDE7AALDH1A1 | |
| SCHEMBL5253210 | 0.73 | PDE7A (0.79) | ITGB2ICAM1ITGALPDE7AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541141-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |
| EP-1175615-A2 | LFA-1 REGULATORY BINDING SITE AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000060355-A2 | LFA-1 REGULATORY BINDING SITE AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |