Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 13/20 | 0.63 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.63 |
| ▸ | CDK2 | P24941 | 13/20 | 0.63 |
| ▸ | CDK4 | P11802 | 7/20 | 0.63 |
| ▸ | CCND1 | P24385 | 7/20 | 0.63 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.63 |
| ▸ | CDK1 | P06493 | 5/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.63 |
| ▸ | CCND3 | P30281 | 4/20 | 0.63 |
| ▸ | CCND2 | P30279 | 1/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5725573 | 0.93 | CCNE2 (0.65) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7522567 | 0.80 | CCNE2 (0.55) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL4734684 | 0.77 | CCNE2 (1.00) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL24732259 | 0.76 | CDK2 (0.64) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7507195 | 0.75 | CCNE2 (0.59) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL5725741 | 0.75 | CDK2 (0.65) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7517274 | 0.75 | CCNE2 (0.53) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL18135139 | 0.74 | CDK2 (0.64) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL21359490 | 0.73 | AOC3 (0.55) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL21770026 | 0.73 | CDK2 (0.53) | CCNE2CCNE1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020165259-A1 | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases | RAWLINS DAVID B (US) | 2002-11-07 | — | — | US | claimed |
| EP-1087951-A4 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL MYERS SQUIBB CO (US) | 2002-08-14 | — | — | EP | claimed |
| EP-1087951-A1 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-04-04 | — | — | EP | claimed |
| WO-1999065884-A1 | CARBON SUBSTITUTED AMINOTHIAZOLE INHIBITORS OF CYCLIN DEPENDENT KINASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165259-A1 | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases | CCNK, CDK2, CCNL2 | CCNE2 23/4885CCNE1 12/4885CDK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.