SCHEMBL7516732

SCHEMBL7516732

O=c1[nH]c(=O)n(COCCO)cc1Cc1cccc(Oc2ccccc2)c1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
UPP1 Q16831 1/20 0.77
DAO P14920 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9163320 0.92 UPP1 (0.65) UPP1
SCHEMBL9164789 0.92 UPP1 (0.65) UPP1
SCHEMBL9169383 0.92 UPP1 (0.65) UPP1
SCHEMBL9163316 0.92 UPP1 (0.65) UPP1
SCHEMBL9169468 0.91 UPP1 (0.66) UPP1
SCHEMBL9164723 0.91 UPP1 (0.66) UPP1
SCHEMBL9166276 0.91 UPP1 (0.66) UPP1
SCHEMBL9167137 0.91 UPP1 (0.66) UPP1
SCHEMBL21067979 0.90 UPP1 (0.74) UPP1
SCHEMBL9170586 0.89 UPP1 (0.60) UPP1DAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001060985-A9 COMPOSITIONS, METHODS AND KITS RELATING TO URIDINE PHOSPHORYLASE GENE MUTATIONS UNIV YALE (US) 2002-10-31 WO claimed
WO-2001060985-A2 COMPOSITIONS, METHODS AND KITS RELATING TO URIDINE PHOSPHORYLASE GENE MUTATIONS YALE UNIVERSITY (US) 2001-08-23 WO claimed
WO-2001060985-A9 COMPOSITIONS, METHODS AND KITS RELATING TO URIDINE PHOSPHORYLASE GENE MUTATIONS UNIV YALE (US) 2002-10-31 WO disclosed
WO-2001060985-A2 COMPOSITIONS, METHODS AND KITS RELATING TO URIDINE PHOSPHORYLASE GENE MUTATIONS YALE UNIVERSITY (US) 2001-08-23 WO disclosed
EP-0649413-A1 URACIL DERIVATIVES AS ENZYME INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1995-04-26 EP disclosed
WO-1994001414-A1 URACIL DERIVATIVES AS ENZYME INHIBITORS THE WELLCOME FOUNDATION LIMITED (GB) 1994-01-20 WO disclosed