Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517223 | 1.00 | TP53 (0.69) | TP53KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7518093 | 0.88 | TP53 (0.53) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL7518090 | 0.88 | TP53 (0.53) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL7512630 | 0.88 | KMT2A (0.56) | TP53KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7511513 | 0.88 | TP53 (0.52) | TP53KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7517950 | 0.88 | KMT2A (0.56) | TP53KMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7511504 | 0.88 | TP53 (0.52) | TP53KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7521366 | 0.86 | TP53 (0.52) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL7521374 | 0.86 | TP53 (0.52) | TP53KMT2ALMNAMAPTMEN1 | |
| SCHEMBL6219542 | 0.85 | TP53 (0.71) | TP53KMT2ALMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807633-B1 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-0807633-A2 | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | PFIZER INC. (US) | 1997-11-19 | — | — | EP | disclosed |