Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.54 |
| ▸ | MTOR | P42345 | 13/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11027619 | 0.93 | PIK3CA (0.60) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL11027341 | 0.92 | PIK3CA (0.59) | PIK3CAMTORPIK3CBKDM4EALDH1A1 | |
| SCHEMBL2790005 | 0.88 | PIK3CA (0.62) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL750596 | 0.87 | PIK3CA (0.56) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL751149 | 0.87 | PIK3CA (0.57) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL756108 | 0.85 | PIK3CA (0.59) | PIK3CAMTORCCNE1CDK2PIK3CB | |
| SCHEMBL752472 | 0.85 | PIK3CA (0.54) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL756457 | 0.85 | PIK3CA (0.56) | PIK3CAMTORKDM4EALDH1A1POLB | |
| SCHEMBL751742 | 0.84 | PIK3CA (0.52) | PIK3CAMTORCCNE1CDK2FGFR3 | |
| SCHEMBL755840 | 0.82 | PIK3CA (0.54) | PIK3CAMTORKDRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |