Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.63 |
| ▸ | HTR2A | P28223 | 6/20 | 0.63 |
| ▸ | DRD3 | P35462 | 6/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.63 |
| ▸ | HRH1 | P35367 | 5/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.63 |
| ▸ | HTR2B | P41595 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7810744 | 0.99 | SLC29A1 (0.75) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Water SCHEMBL7526796 | 0.99 | SLC29A1 (0.75) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Water SCHEMBL9362242 | 0.99 | SLC29A1 (0.75) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| SCHEMBL9030901 | 0.90 | SLC29A1 (0.64) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| SCHEMBL7808271 | 0.88 | SLC29A1 (0.80) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Draflazine SCHEMBL215826 | 0.87 | SLC29A1 (1.00) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Draflazine SCHEMBL7705425 | 0.87 | SLC29A1 (1.00) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Draflazine SCHEMBL9410932 | 0.86 | SLC29A1 (0.98) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Hydrochloric Acid SCHEMBL9808242 | 0.86 | SLC29A1 (0.86) | SLC29A1KCNH2HTR2ADRD3OPRK1 | |
| Draflazine SCHEMBL9362256 | 0.86 | SLC29A1 (0.98) | SLC29A1KCNH2HTR2ADRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577171-B1 | Use of piperazine acetamide derivatives against reperfusion damage | JANSSEN PHARMACEUTICA NV (BE) | 2002-03-06 | — | — | EP | claimed |
| EP-0727421-B1 | Agents for improving sleep | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | claimed |
| EP-0577171-B1 | Use of piperazine acetamide derivatives against reperfusion damage | JANSSEN PHARMACEUTICA NV (BE) | 2002-03-06 | — | — | EP | disclosed |
| EP-0727421-B1 | Agents for improving sleep | JANSSEN PHARMACEUTICA NV (BE) | 2001-10-24 | — | — | EP | disclosed |
| EP-0285219-B1 | Method of improving sleep | JANSSEN PHARMACEUTICA NV (BE) | 1996-09-11 | — | — | EP | disclosed |
| EP-0727421-A1 | Agents for improving sleep | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0455789-B1 | METHOD OF PREVENTING OR LIMITING REPERFUSION DAMAGE | JANSSEN PHARMACEUTICA NV (BE) | 1994-03-16 | — | — | EP | disclosed |
| EP-0285219-A2 | Method of improving sleep | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-10-05 | — | — | EP | disclosed |