Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 7/20 | 0.46 |
| ▸ | RARG | P13631 | 7/20 | 0.46 |
| ▸ | RARA | P10276 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517611 | 0.92 | MEN1 (0.53) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929991 | 0.91 | KMT2A (0.44) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7929545 | 0.83 | RARB (0.47) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL8438827 | 0.83 | MEN1 (0.66) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7515780 | 0.81 | RARB (0.51) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL8457461 | 0.80 | RARB (0.48) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL29462745 | 0.80 | IKBKB (0.52) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL2919467 | 0.80 | IKBKB (0.52) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL7518648 | 0.79 | MEN1 (0.64) | MEN1KMT2ATHRBRECQLNR2E1 | |
| SCHEMBL8657238 | 0.79 | MEN1 (0.76) | MEN1KMT2ATHRBRECQLNR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854711-B1 | gamma-RAR ANTAGONIST LIGAND OR alpha-RAR AGONIST LIGAND AS AN APOPTOSIS INHIBITOR | GALDERMA RECH DERMATOLOGIQUE (FR) | 2002-01-23 | — | — | EP | claimed |
| US-6063797-A | γ-RAR antagonist ligand or α-RAR agonist ligand as an apoptosis inhibitor | C.I.R.D. GALDERMA (FR) | 2000-05-16 | — | — | US | claimed |
| EP-0658553-B1 | Polycyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1998-11-04 | — | — | EP | claimed |
| US-6225328-B1 | FOR THERAPY OF DISORDERS OR AILMENTS RELATED TO AN OVERREGULATION OF RETINOIC ACID RECEPTORS AND/OR TO HYPERVIAMINOSIS A | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2001-05-01 | — | — | US | disclosed |
| US-6063797-A | γ-RAR antagonist ligand or α-RAR agonist ligand as an apoptosis inhibitor | C.I.R.D. GALDERMA (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0658553-B1 | Polycyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1998-11-04 | — | — | EP | disclosed |
| EP-0740937-A2 | Use of retinoids for the manufacture of a pharmaceutical or cosmetic composition | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-11-06 | — | — | EP | disclosed |
| EP-0658553-A1 | Polycyclic aromatic compounds, pharmaceutical compositions containing them and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-06-21 | — | — | EP | disclosed |