Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520909 | 0.88 | PARP1 (0.53) | PARP1PARP2 | |
| SCHEMBL7522321 | 0.88 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL7524922 | 0.88 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL3992291 | 0.88 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL7525305 | 0.88 | PARP1 (0.55) | PARP1PARP2 | |
| SCHEMBL3989767 | 0.87 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL3992894 | 0.86 | PARP1 (0.71) | PARP1PARP2 | |
| SCHEMBL6872238 | 0.86 | PARP1 (0.68) | PARP1PARP2 | |
| SCHEMBL3989730 | 0.85 | PARP1 (0.52) | PARP1PARP2 | |
| SCHEMBL7519317 | 0.85 | PARP1 (0.52) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171424-A1 | CYCLO-ALKYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000064878-A1 | CYCLO-ALKYL SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-02 | — | — | WO | disclosed |