Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 9/20 | 0.66 |
| ▸ | TACR1 | P25103 | 2/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.59 |
| ▸ | CTSS | P25774 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841663 | 0.91 | FOLH1 (0.58) | CTSLTACR1CTSSCTSK | |
| SCHEMBL7515531 | 0.91 | FOLH1 (0.58) | CTSLTACR1CTSSCTSK | |
| SCHEMBL11071178 | 0.89 | MME (0.67) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL16095807 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL30241933 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL30688477 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL8100557 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL10049956 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL12052836 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK | |
| SCHEMBL10722852 | 0.89 | TACR1 (0.70) | CTSLTACR1CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |