Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525778 | 0.94 | PDE5A (0.51) | PDE5AKMT2APDGFRBEGFRCSF1R | |
| SCHEMBL7521937 | 0.94 | PDE5A (0.57) | PDE5AKMT2APDGFRBEGFRCSF1R | |
| SCHEMBL7525743 | 0.93 | PDE5A (0.57) | PDE5AKMT2APDGFRBEGFRCSF1R | |
| SCHEMBL7521436 | 0.91 | PDE5A (0.48) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7523947 | 0.91 | PDE5A (0.48) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7520624 | 0.90 | PDE5A (0.47) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7521455 | 0.89 | EGFR (0.48) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7527697 | 0.88 | EGFR (0.48) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7530560 | 0.88 | EGFR (0.48) | PDE5AKMT2APDGFRBEGFRACHE | |
| SCHEMBL7526254 | 0.88 | EGFR (0.48) | PDE5AKMT2APDGFRBEGFRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020193389-A1 | Method of inhibiting neoplastic cells with imidazoquinazoline derivatives | OSI PHARMACEUTICALS, INC. | 2002-12-19 | — | — | US | disclosed |
| US-6127541-A | 8-((DISUBSTITUTED AMINO)BENZYLAMINO)-2,3-DIHYDRO-1H-IMIDAZO(4,5-G)QUINAZOLINE-(2-THIONE OR 2-ONE); SELECTIVE CYCLIC GUANOSINE 3',5' MONOPHOSPHATE (CGMP)--SPECIFIC PHOSPHODIESTERASE (PDE) INHIBITORY ACTIVITY | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0863144-A1 | IMIDAZOQUINAZOLINE DERIVATIVES | Kyowa Hakko Co., Ltd. (JP) | 1998-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193389-A1 | Method of inhibiting neoplastic cells with imidazoquinazoline derivatives | MKI67, HRAS, VHL | PDE5A 3373/4885KMT2A 1337/4885PDGFRB 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.