Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HBB | P68871 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512181 | 0.91 | PNP (0.61) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL23648144 | 0.91 | PNP (0.61) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17521211 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL29502677 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL9141685 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL23352546 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL657819 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL21162582 | 0.88 | PNP (0.62) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL7521688 | 0.85 | PNP (0.59) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL8830322 | 0.84 | PNP (0.46) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495346-B1 | DO NOT REACT WITH FOREIGN PARTNERS; AMINO ACIDS INSERTED INTO PROTEINS WHICH NATURALLY FORM DIMERS, MUTATED PROTEINS ONLY FORM COMPLEXES WITH THEMSELVES (HOMODIMERS) OR WITH THE MUTATED PARTNER (HETERODIMERS), NOT WITH NONMUTATED STARTING | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-12-17 | — | — | US | disclosed |