Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL27466268 | 0.96 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL16444321 | 0.96 | CYP3A4 (0.32) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL27684219 | 0.93 | SLC7A5 (0.34) | SLC7A5 | |
| Histidine SCHEMBL18280908 | 0.92 | CYP3A4 (0.30) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL27902238 | 0.92 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSC | |
| D-Histidine SCHEMBL11606906 | 0.92 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL2586203 | 0.92 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL2586200 | 0.92 | SLC7A5 (0.35) | CYP3A4SLC7A5CTSC | |
| Histidine SCHEMBL7753923 | 0.91 | SLC7A5 (0.30) | SLC7A5 | |
| Histidine SCHEMBL7763229 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020155450-A1 | Genetic polymorphisms which are associated with autism spectrum Disorders | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2002-10-24 | — | — | US | disclosed |
| US-6228582-B1 | SCREENING FOR BRAIN DISORDERS; ISOLATE MAMMALIAN TISSUE SAMPLE, TEST SAMPLE FOR PREFERENTIAL POLYMORPHISM IN NUCLEOTIDE SEQUENCES | UNIVERSITY OF ROCHESTER | 2001-05-08 | — | — | US | disclosed |