Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL31527591 | 1.00 | HDAC8 (0.43) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| SCHEMBL10257334 | 0.98 | — | — | |
| SCHEMBL9602287 | 0.80 | HSD17B10 (0.47) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| Iodide SCHEMBL28825378 | 0.79 | HSD17B10 (0.44) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| Iodide SCHEMBL14633634 | 0.79 | HDAC8 (0.44) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| Iodide SCHEMBL26981893 | 0.77 | HDAC8 (0.43) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| SCHEMBL13822326 | 0.77 | HSD17B10 (0.45) | HDAC8KDM4ESMN1; SMN2HSD17B10ACHE | |
| SCHEMBL329433 | 0.76 | — | — | |
| SCHEMBL29729219 | 0.76 | — | — | |
| Iodide SCHEMBL4408127 | 0.76 | KCNH2 (0.48) | HDAC8KDM4ESMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1172691-A1 | Method of processing photographic silver-dye-bleach materials and bleaching solution preparations therefor | ILFORD Imaging Switzerland GmbH (CH) | 2002-01-16 | — | — | EP | disclosed |
| US-4879413-A | PHOTOGRAPHIC BLEACHING | CIBA-GEIGY AG (CH) | 1989-11-07 | — | — | US | disclosed |
| US-4701525-A | Polyazo dyestuffs having high UV absorption | CIBA-GEIGY AG (CH) | 1987-10-20 | — | — | US | disclosed |
| US-4609609-A | ULTRAVIOLET | CIBA GEIGY AG (CH) | 1986-09-02 | — | — | US | disclosed |
| US-4575482-A | BRILLIANCE, LIGHTFASTNESS | CIBA-GEIGY AG (CH) | 1986-03-11 | — | — | US | disclosed |
| US-4521591-A | Oil-soluble disazo dyes and their use in color-photographic recording materials for the silver dye bleach process | CIBA-GEIGY AG (CH) | 1985-06-04 | — | — | US | disclosed |
| US-4456668-A | DYE BLEACH, TEXTILE DYES | CIBA GEIGY AG (CH) | 1984-06-26 | — | — | US | disclosed |
| US-4409143-A | TEXTILES, PHOTOGRAPHY | CIBA-GEIGY AG (CH) | 1983-10-11 | — | — | US | disclosed |
| US-4379819-A | OIL SOLUBLE MONOAZO DYE | CIBA-GEIGY AG (CH) | 1983-04-12 | — | — | US | disclosed |
| US-4369318-A | USING A BENZO-OR PYRIDO-CINNOLINES AS BLEACH CATALYST | CIBA-GEIGY LTD. (CH) | 1983-01-18 | — | — | US | disclosed |
| US-4366232-A | Method for processing photographic silver dye-bleach materials and suitable preparations | CIBA-GEIGY LTD. (CH) | 1982-12-28 | — | — | US | disclosed |
| US-4304846-A | USING MIXTURES OF A 1,4- OR 1,2-DIAZINE AS BLEACHING CATALYSTS; PREFERENTIAL REDOX POTENTIALS | CIBA-GEIGY AG (CH) | 1981-12-08 | — | — | US | disclosed |
| US-4266011-A | FUSED PYRIDAZINE CATALYST | CIBA-GEIGY AG (CH) | 1981-05-05 | — | — | US | disclosed |