Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 9/20 | 0.47 |
| ▸ | CAPNS1 | P04632 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810081 | 0.89 | CAPN1 (0.49) | CAPN1CAPNS1KMT2AAIMP2MEN1 | |
| SCHEMBL8810089 | 0.89 | CAPN1 (0.49) | CAPN1CAPNS1KMT2AAIMP2MEN1 | |
| SCHEMBL8406511 | 0.88 | CAPN1 (0.49) | CAPN1CAPNS1CTSLCTSSCTSK | |
| SCHEMBL7514483 | 0.88 | CAPN1 (0.49) | CAPN1CAPNS1CTSLCTSSCTSK | |
| SCHEMBL8406503 | 0.88 | CAPN1 (0.49) | CAPN1CAPNS1CTSLCTSSCTSK | |
| SCHEMBL8404242 | 0.88 | CAPN1 (0.54) | CAPN1CAPNS1CTSLCTSSCTSK | |
| SCHEMBL8404247 | 0.88 | CAPN1 (0.54) | CAPN1CAPNS1CTSLCTSSCTSK | |
| SCHEMBL8403866 | 0.88 | CAPN1 (0.50) | CAPN1CAPNS1KMT2AAIMP2MEN1 | |
| SCHEMBL8403869 | 0.88 | CAPN1 (0.50) | CAPN1CAPNS1KMT2AAIMP2MEN1 | |
| SCHEMBL8404230 | 0.84 | CAPN1 (0.54) | CAPN1CAPNS1CTSKKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |