SCHEMBL7523448

SCHEMBL7523448

O=C=Nc1ccc(Br)cc1.O=C=Nc1ccc(F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.47
TSHR P16473 1/20 0.47
MAPK1 P28482 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
NPC1 O15118 3/20 0.38
RAB9A P51151 2/20 0.38
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
TRPA1 O75762 1/20 0.37
CYP1A2 P05177 2/20 0.37
POLB P06746 1/20 0.37
CYP2D6 P10635 1/20 0.37
SLC22A2 O15244 2/20 0.34
SLC22A1 O15245 2/20 0.34
SLC22A3 O75751 2/20 0.34
PLAU P00749 2/20 0.34
GLB1 P16278 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL93221 0.89 CYP3A4 (0.56) CYP3A4TSHRMAPK1TDP1NPC1
SCHEMBL93163 0.89 CYP3A4 (0.56) CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL5862066 0.83 CYP3A4 (0.50) CYP3A4TSHRMAPK1TDP1NPC1
Fluorobenzene SCHEMBL2828466 0.81 CYP3A4 (0.48) CYP3A4TSHRMAPK1TDP1NPC1
Methylene Chloride SCHEMBL28101789 0.81 CYP3A4 (0.54) CYP3A4TSHRMAPK1TDP1MAPT
SCHEMBL8093595 0.79 TDP1 (0.48) CYP3A4TSHRMAPK1TDP1NPC1
SCHEMBL11025348 0.78 MAPT (0.47) CYP3A4TSHRMAPK1TDP1LMNA
SCHEMBL15430 0.76 CYP3A4 (0.70) CYP3A4TSHRMAPK1TDP1TRPA1
SCHEMBL8942928 0.75 NPC1 (0.45) CYP3A4TSHRMAPK1TDP1NPC1
Ether SCHEMBL596696 0.75 CYP3A4 (0.47) CYP3A4TSHRMAPK1TDP1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP disclosed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO disclosed
WO-1998057173-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PHENYLALANINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-12-17 WO disclosed