⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448583 | 0.65 | CHEK1 (0.37) | — | |
| SCHEMBL28151351 | 0.65 | — | — | |
| SCHEMBL15326918 | 0.65 | — | — | |
| SCHEMBL30100337 | 0.65 | CHEK1 (0.37) | — | |
| SCHEMBL1749731 | 0.65 | — | — | |
| SCHEMBL30481014 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL28097181 | 0.64 | HSP90AA1 (0.38) | — | |
| SCHEMBL27566429 | 0.62 | HSP90AA1 (0.31) | — | |
| SCHEMBL3955042 | 0.62 | HSP90AA1 (0.40) | — | |
| SCHEMBL27476206 | 0.62 | RAD52 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934290-B1 | AMINOTHIAZOLE DERIVATIVES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2002-04-17 | — | — | EP | claimed |
| US-20020137740-A1 | Aminothiazole derivatives, process for preparing them and pharmaceutical compositions containing them | FONTAINE EVELYNE (FR) | 2002-09-26 | — | — | US | disclosed |
| US-6344470-B1 | Aminothiazole derivatives, method of preparation and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2002-02-05 | — | — | US | disclosed |