Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103746 | 0.84 | CNR1 (0.44) | SLC22A12MAPTKMT2APDE5A | |
| SCHEMBL176824 | 0.83 | SLC22A12 (0.53) | SLC22A12SLC16A3KHKPDE5A | |
| SCHEMBL11975934 | 0.83 | SLC22A12 (0.67) | SLC22A12 | |
| SCHEMBL683164 | 0.82 | ADORA2A (0.43) | SLC22A12PTGDR2MAPTGAAAKR1B1 | |
| SCHEMBL8373357 | 0.82 | SLC16A3 (0.58) | SLC22A12MAPTSLC16A3ALDH1A1CYP1A2 | |
| SCHEMBL11977395 | 0.81 | SLC22A12 (0.67) | SLC22A12PTGDR2AKR1B1 | |
| SCHEMBL2551135 | 0.80 | KHK (0.61) | ALDH1A1KHK | |
| SCHEMBL683169 | 0.80 | ADORA2A (0.46) | SLC22A12PTGDR2AKR1B1ALDH1A1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL906049 | 0.78 | ADORA2A (0.45) | SLC22A12PTGDR2AKR1B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL906047 | 0.75 | HTR2C (0.51) | SLC22A12CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983249-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING SUBSTITUTED INDAZOLE DERIVATIVES | PFIZER PROD INC (US) | 2002-03-13 | — | — | EP | disclosed |
| US-6011159-A | Processes and intermediates for preparing substituted indazole derivatives | PFIZER INC (US) | 2000-01-04 | — | — | US | disclosed |