Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526114 | 0.93 | ESR1 (0.63) | ESR1ESR2HRH3KCNH2PTPN1 | |
| SCHEMBL7530403 | 0.92 | ESR1 (0.61) | ESR1ESR2HRH3KCNH2PTPN1 | |
| SCHEMBL7530398 | 0.92 | ESR1 (0.64) | ESR1ESR2 | |
| SCHEMBL7527931 | 0.91 | ESR1 (0.60) | ESR1ESR2HRH3KCNH2PTPN1 | |
| SCHEMBL7527272 | 0.90 | ESR1 (0.59) | ESR1ESR2HRH3KCNH2PTPN1 | |
| SCHEMBL7525891 | 0.89 | ESR1 (0.59) | ESR1ESR2HRH3KCNH2 | |
| SCHEMBL8965793 | 0.88 | ESR1 (0.68) | ESR1ESR2HRH3KCNH2 | |
| SCHEMBL8966242 | 0.88 | ESR1 (0.68) | ESR1ESR2HRH3KCNH2 | |
| SCHEMBL7527242 | 0.87 | ESR1 (0.66) | ESR1ESR2HRH3KCNH2 | |
| SCHEMBL8966126 | 0.87 | ESR1 (0.66) | ESR1ESR2HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |