Tempol Hydroxylamine

Tempol Hydroxylamine

SCHEMBL7526287

CC1(C)CC(O)CC(C)(C)N1O.CC1(C)CC(O)CC(C)(C)N1O.O=C(O)C(=O)O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

OPRM1SLC6A4

The experimentally established mechanism targets of Tempol Hydroxylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 1/20 0.36
ALOX15 P16050 1/20 0.36
APLNR P35414 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tempol Hydroxylamine SCHEMBL27512719 1.00 GAA (0.46) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL986355 0.91 GAA (0.46) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL23902 0.88 GAA (0.56) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL7099824 0.86 GAA (0.50) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL987556 0.85 GAA (0.54) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL28364622 0.85 GAA (0.42) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL5198256 0.85 GAA (0.42) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL2867127 0.82 GAA (0.39) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL7516297 0.82 GAA (0.46) GAAL3MBTL1KDM4EALDH1A1ALOX15
Tempol Hydroxylamine SCHEMBL31285654 0.82 GAA (0.46) GAAL3MBTL1KDM4EALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500303-B1 DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL; PROTECTION FROM ULTRAVIOLET, FLUORESCENT AND SUN LIGHT EXPOSURE CIBA SPECIALTY CHEMICALS CORPORATION 2002-12-31 US disclosed
US-20020124980-A1 Inhibition of pulp and paper yellowing using nitroxides, hydroxylamines and other coadditives SELTZER RAYMOND R (US) 2002-09-12 US disclosed
US-6447644-B1 PULP OR PAPER THAT STILL CONTAINS LIGNIN, AND A STERICALLY HINDERED AMINE, FOR EXAMPLE DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL CIBA SPECIALTY CHEMICALS CORPORATION 2002-09-10 US disclosed
US-6254724-B1 STABILIZING AMOUNT OF A HINDERED AMINE COMPOUND SELECTED DERIVATIVES OF 1-OXYL-2,2,6,6-TETRAMETHYL-PIPERIDIN-4-OL OR WHICH ARE THEIR HYDROXYLAMINE SALTS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-03 US disclosed
EP-1000032-A1 INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES Ciba SC Holding AG (CH) 2000-05-17 EP disclosed
WO-1999005108-A1 INHIBITION OF PULP AND PAPER YELLOWING USING NITROXIDES AND OTHER COADDITIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1999-02-04 WO disclosed