Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2075108 | 0.96 | POLB (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31687156 | 0.96 | POLB (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2076187 | 0.87 | TP53 (0.40) | CA1CA2CA7CA9SMN1; SMN2 | |
| SCHEMBL14626050 | 0.81 | CA1 (0.53) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10599920 | 0.77 | POLB (0.48) | POLBGLATP53ADRB2ADRB1 | |
| SCHEMBL8276835 | 0.76 | TP53 (0.56) | POLBSMN1; SMN2TP53CYP2C9 | |
| SCHEMBL3200431 | 0.74 | POLB (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL38660212 | 0.74 | POLB (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15528799 | 0.73 | NOTUM (0.53) | — | |
| SCHEMBL1021359 | 0.72 | NOTUM (0.64) | SMN1; SMN2MAPK1TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181269-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000073264-A1 | CELL PROLIFERATION INHIBITORS | ABBOTT LABORATORIES (US) | 2000-12-07 | — | — | WO | disclosed |