⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30855463 | 1.00 | — | — | |
| SCHEMBL20489251 | 1.00 | TP53 (0.53) | — | |
| SCHEMBL30855464 | 1.00 | — | — | |
| SCHEMBL752377 | 1.00 | — | — | |
| SCHEMBL27579 | 1.00 | — | — | |
| SCHEMBL28814082 | 0.96 | — | — | |
| SCHEMBL28601533 | 0.96 | — | — | |
| Water SCHEMBL4557071 | 0.96 | — | — | |
| Methyl Alcohol SCHEMBL11103337 | 0.96 | — | — | |
| Ammonia Solution, Strong SCHEMBL3896169 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12496296-B2 | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases | ALKAHEST, INC. (US) | 2025-12-16 | — | — | US | claimed |
| EP-4426284-A1 | BENZODIOXANE MODULATORS OF LEUKOTRIENE A4 HYDROLASE (LTA4H) FOR PREVENTION AND TREATMENT OF AGING-ASSOCIATED DISEASES | Alkahest, Inc. (US) | 2024-09-11 | — | — | EP | claimed |
| US-20240252478-A1 | Benzodioxane Modulators of Leukotriene A4 Hydrolase (LTA4H) for Prevention and Treatment of Aging-Associated Diseases | ALKAHEST, INC. | 2024-08-01 | — | — | US | claimed |
| US-11957671-B2 | Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases | ALKAHEST, INC. (US) | 2024-04-16 | — | — | US | claimed |
| US-20230312548-A1 | SUBSTITUTE FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | VTV THERAPEUTICS LLC | 2023-10-05 | — | — | US | claimed |
| US-11649230-B2 | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof | VTV THERAPEUTICS LLC (US) | 2023-05-16 | — | — | US | claimed |
| US-20230146135-A1 | Benzodioxane Modulators of Leukotriene A4 Hydrolase (LTA4H) for Prevention and Treatment of Aging-Associated Diseases | ALKAHEST, INC. | 2023-05-11 | — | — | US | claimed |
| WO-2023076679-A1 | BENZODIOXANE MODULATORS OF LEUKOTRIENE A4 HYDROLASE (LTA4H) FOR PREVENTION AND TREATMENT OF AGING-ASSOCIATED DISEASES | ALKAHEST, INC. (US) | 2023-05-04 | — | — | WO | claimed |
| US-20220169641-A1 | Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof | VTVX HOLDINGS II LLC | 2022-06-02 | — | — | US | claimed |
| US-11130753-B2 | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof | VTV THERAPEUTICS LLC (US) | 2021-09-28 | — | — | US | claimed |
| WO-2009110985-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2009-09-11 | — | — | WO | claimed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | claimed |
| CN-1980661-A | Cationic bacteriochlorophyll derivatives and uses thereof | YEDA RES & DEV (IL) | 2007-06-13 | — | — | CN | claimed |
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | claimed |
| US-20060063778-A1 | Hydroxamic acid derivatives | NOVARTIS AG (CH) | 2006-03-23 | — | — | US | claimed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | claimed |
| EP-1497273-A2 | HYDROXAMIC ACID DERIVATIVES | Novartis AG (CH) | 2005-01-19 | — | — | EP | claimed |
| WO-2003084941-A2 | HYDROXAMIC ACID DERIVATIVES | NOVARTIS AG (CH) | 2003-10-16 | — | — | WO | claimed |
| EP-0394311-A1 | RENIN INHIBITING PEPTIDES THAT CONTAIN AMINO AND HYDROXY DICARBOXYLIC ACIDS | THE UPJOHN COMPANY (US) | 1990-10-31 | — | — | EP | claimed |
| WO-1989004833-A1 | RENIN INHIBITING PEPTIDES THAT CONTAIN AMINO AND HYDROXY DICARBOXYLIC ACIDS | THE UPJOHN COMPANY (US) | 1989-06-01 | — | — | WO | claimed |