SCHEMBL7527359

SCHEMBL7527359

COc1ccc(/C=C/c2ccc(NC(=O)c3ccc(N(C)C(=O)c4ccc(C(=O)O)cc4)cc3)c(C(=O)O)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.56
KMT2A Q03164 4/20 0.51
MEN1 O00255 3/20 0.51
APP P05067 4/20 0.51
KCNK2 O95069 1/20 0.49
SNCA P37840 2/20 0.48
F10 P00742 2/20 0.47
PKM P14618 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA9 Q16790 1/20 0.46
PLK1 P53350 1/20 0.46
PLK3 Q9H4B4 1/20 0.46
XDH P47989 1/20 0.44
NPC1 O15118 1/20 0.43
TRPA1 O75762 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7648400 0.94 MAPT (0.54) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7647418 0.94 APP (0.49) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7647393 0.94 APP (0.49) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7528663 0.90 SNCA (0.49) MAPTKMT2AMEN1APPSNCA
SCHEMBL7527005 0.88 KDM4E (0.51) MAPTKMT2AMEN1APPSNCA
SCHEMBL7528550 0.88 KDM4E (0.51) MAPTKMT2AMEN1APPSNCA
SCHEMBL7530323 0.88 KCNK2 (0.47) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7527352 0.87 MAPT (0.57) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7527364 0.87 MAPT (0.57) MAPTKMT2AMEN1APPKCNK2
SCHEMBL7648625 0.86 APP (0.46) APPSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US claimed
US-6479548-B2 P-(BENZOYLAMINO)STILBENE DERIVATIVES TELIK, INC. 2002-11-12 US disclosed
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers SLC2A1, SLC2A8, SLC2A2 MAPT 2920/4885KMT2A 3788/4885MEN1 2354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.