Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.56 |
| ▸ | MTOR | P42345 | 6/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028687 | 0.80 | PIK3CA (0.48) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7887709 | 0.80 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL11030618 | 0.76 | MAPKAPK2 (0.43) | LMNAHTTNPSR1SMN1; SMN2MAPT | |
| SCHEMBL11892543 | 0.76 | SMN1; SMN2 (0.41) | PIK3CAMTORLMNAHTTNPSR1 | |
| SCHEMBL750383 | 0.74 | PIK3CA (0.53) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL751161 | 0.73 | TSHR (0.36) | PIK3CAMTORLMNAHTTNPSR1 | |
| SCHEMBL3787339 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL752861 | 0.72 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL12781962 | 0.67 | FLT3 (0.48) | PIK3CAMTORALOX15 | |
| SCHEMBL1318687 | 0.66 | SYK (0.63) | GFERKMT2ATSHRMEN1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | claimed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | PIK3CA 1/4885MTOR 21/4885PIK3CD 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.