Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 8/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | BRD4 | O60885 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL748521 | 0.95 | MAPT (0.64) | MAPTHPGDALOX15HTTTDP1 | |
| Potassium Ion SCHEMBL751004 | 0.93 | MAPT (0.61) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL2265371 | 0.89 | MAPT (0.65) | MAPTHPGDALOX15HTTTDP1 | |
| Potassium Ion SCHEMBL751005 | 0.86 | MAPT (0.58) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL749053 | 0.86 | BRD4 (0.71) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL748870 | 0.84 | MAPT (0.58) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL750902 | 0.83 | MAPT (0.57) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL748501 | 0.83 | MAPT (0.57) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL2266490 | 0.83 | MAPT (0.72) | MAPTHPGDALOX15HTTTDP1 | |
| SCHEMBL2266741 | 0.83 | MAPT (0.56) | MAPTHPGDALOX15HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430024-A1 | [1,2,4]TRIAZOLO [4,3-B]PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | AstraZeneca AB (SE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | AR, NR5A1, KLK3 | MAPT 2874/4885HPGD 672/4885ALOX15 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.